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Whenever estrogen is suggested as a therapeutic aid, the question immediately arises: "Aren't you afraid of cancer?" To make the situation officially worse, the pharmacist is required by the F.D.A. to include a package insert with every prescription of estrogen, warning the patient of the danger of taking it. At every opportunity, the press and the television make comments about the possibility of estrogen causing cancer. Some of our finest physicians and surgeons are adamant in their opposition to estrogen supplementation. Their prejudice completely outweighs their reason. They usually cannot give reasons for their opposition.