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Complete Natural Vitamin B Complex and Associated Synergists From All Therapeutically Active Sources
Published in Vitamin News, Vol. 8, 1940.
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Above we have most of the known factors of the complete natural vitamin B complex. Although many of them have no established effect on humans, it is the experience of the clinical users of “V-P” complete natural vitamin B Complex, No. 712, that they are necessary in natural balance to act as synergists with more specific factors. A natural combination such as this is likely, according to clinical experience, to be from ten to fifty times more potent in humans, unit for unit, than is a chemically purified or synthetic complex, or a natural complex derived from only ONE source. No ONE source contains ALL the factors of the complete vitamin B complex, and for highest potency a number of therapeutically active sources must be tapped. Although only 22 factors and synergists are listed, ten or more in addition are indicated and are combined in such organic combinations as to make, in some cases 50 to 100 isomers, while only one is therapeutically active. The futility of attempting to synthesize or tamper chemically with these extremely complicated food factors is thus obvious.
In clinical substantiation of the.above information, are the remarkably successful results and higher potencies exhibited by “V-P” Vitamin B Complex in the treatment of cardiac fibrillation, arrhythmias, dilatations, and myocardial weakness.
References Cited in chart above:
- Williams, R. R. and Spies, T. D., Vitamin B1, The Macmillan Co., N. Y., 1938.
- Stepp, W., Kuhnau, J. and Schroder, H., The Vitamins and Their Clinical Application, F. Enke, Stuttgart, Germany, 1936 (translation by Vitamin Products Company, 1938).
- Matthews, A. P., Physiological Chemistry, Sixth Edition, Williams & Wilkins Co., Baltimore, 1939.
- United States Department of Agriculture Yearbook (1939), U. S. Govt. Printing Office, 1939.
- Carter, C. W., “Maintenance Nutrition in the Pigeon and Its Relation to Heart Block,” Biochemical Journal, 1934.
- Journal of the American Medical Association, Editorial, 112, 13:1258, 1939.
Because of its interest in this connection we are repeating the following material from page 130 of Vitamin News.
The difference between complexes and the pure vitamins is very well indicated by their value in supplying nutrition to yeast. The yeast plant requires vitamins of the B and G groups to live. It takes up these vitamins from the media it lives in, and concentrates them to some extent thereby. We offer graphic charts to show the great difference in the life-giving properties of our “V-P” Complexes as compared to the chemically pure substitutes, unit for unit.
There is much the same variation in results in the use of these vitamin products in treating human vitamin deficiencies. That is why the unit offers no reasonable basis for comparing the nutritive value of different vitamin products, or their therapeutic values either.
Effect of “V-P” Vitamin B Complex on Yeast Growth
Notes on natural C complex:–The most serious symptom of Vitamin C deficiency is susceptibility to infection.4 This may precede actual scurvy. The anti-pneumonia factor (Vitamin J) has not yet been isolated or identified. Absorption and retention of the various ascorbic acid factors from food is greater than from synthetic sources.2 This indicates that, milligram for milligram, natural ascorbic acid complexes are more potent than synthetic ascorbic acid. Synthetic vitamin C will not cure scurvy, because other factors of the complete complex are necessary. V-P natural vitamin C complex has always been more productive of clinical results than synthetic vitamin C, especially in promoting phagocytic activity.
Notes on natural D complex:–What we call vitamin D is not a single identity but a complete complex of known and unknown factors.5 The toxicity of irradiated synthetic preparations, as Viosterol,7 is not present in natural forms containing the synergists. The vitamin D unit is not a reliable criterion of potency, there being species variations of as much as 100 to 1.5,8
Notes on natural E complex:–Drs. Gordon and Sevringhaus13 suggest that vitamin E will be found to be a complex, requiring the combined action of all factors for proper action. They also review our inability to establish human requirements or determine potency in units.
Notes on natural F complex:–The chemistry of vitamin F compounds is not well developed except that we know they are unsaturated fatty acids. Their complexity can readily be imagined when we realize that arachidonic acid can have 256 isomers, of which only one might be clinically effective. Clinical reports on the effectiveness of V-P vitamin F complex in cold sores, fever blisters, scaliness of the skin, falling hair, and dandruff have been particularly encouraging. Its effect in lowering the serum calcium make it a logical protector against vitamin D toxicosis, thus explaining its presence as a synergist of vitamin D in cod-liver oil.6 Vitamin F also is phenomenally rapid in its action of raising the blood iodine.20
Vitamin G Complex
Notes on natural G complex:–The factors composing the vitamin G complex are present in the vitamin B complex. Both B and G complexes are soluble in water, but the G factors are precipitated out in 85% alcohol. These factors embrace the entire thermostable components of the complete B complex, plus other unknown synergists (shown on page 135 of Vitamin News). Clinically, V-P vitamin G complex has been most productive of results when used in relieving the distressing symptoms of peptic ulcers. The G complex is basically a combination of growth and regenerative factors, thus accounting for its efficacy in various gastrointestinal degenerative inflammations. The unknown parts of this complex from cereal seedlings and grass juice are probably the most therapeutically active in this respect.
References Cited:
- Eddy, W. H., What Are the Vitamins? Reinhold Publishing Company, New York, 1941.
- Hawley, Estelle E., Daggs, R. G. and Stephens, D. J., “The Effect of the Administration of Acid and Alkaline Salts upon the Ascorbic Acid Content of Guinea Pig Tissues,” Journal of Nutrition, 14, 1:1-8, July 10, 1937.
- Stepp, Kuhnau and Schroeder, The Vitamins and Their Clinical Application, Ferdinand Enke, Stuttgart, Germany. Translation by Vitamin Products Company, Milwaukee, Wisconsin, 1938.
- Proceedings of the Society for Experimental Biology and Medicine, pages 1089, 1157, April, 1935.
- Reed, C. I., Struck, H. C. and Steck, I. E., Vitamin D, The University of Chicago Press, 1939.
- Burr, G. O. and Burr, M. M., “On the Nature and Role of the Fatty Acids Essential in Nutrition,” Journal of Biological Chemistry, 86:587-621, 1930.
- Brehm, “Potential Dangers of Viosterol during Pregnancy with Observations of Calcification of Placentae,” Ohio Surgical and Medical Journal, 33:990, 1937.
- Bunker, J. W. M. and Harris, R. S., “The Clinical Status of Vitamin D Milks,” New England Journal of Medicine, 211, 25:1140-1147, December 20, 1934.
- Goettsch, Marianne and Ritzmann, Johana, “The Preventive Effect of Wheat-Germ Oils and of Alpha-Tocopherol in Nutritional Muscular Dystrophy of Young Rats,” Journal of Nutrition, 17,4:371-381, April, 1939.
- Emerson, Oliver H., Emerson, Gladys A. and Evans, Herbert M., “The Vitamin E Activity of Alpha-Tocoquinone,” Journal of Biological Chemistry, 131,2:409-412, December, 1939.
- Evans, Herbert M., Emerson, Oliver H. and Emerson, Gladys A., “The Isolation from Wheat Germ Oil of an Alcohol Alpha-Tocopherol, Having the Properties of Vitamin E,” Journal of Biological Chemistry, 113:319, 1936.
- Emerson, et at, Science, 84:421, 1936.
- Gordon and Sevringhaus, Vitamin Therapy in General Practice, pages 133, 139, Year Book Publishers, Chicago, 1940.
- 1939 Yearbook of Agriculture, Food and Life, page 158, U. S. Government Printing Office, Washington, D. C.
- Harris, Leslie J., “Vitamins,” 4:331-382, Annual Review of Biochemistry, 4:371, 1935.
- Biochemical Journal, 24:233-238, 1938.
- Journal of Biological Chemistry, 97:183, 1932.
- Lea, C. H., Rancidity in Edible Fats, pages 164, 169, Chemical Publishing Co., New York, 1939.
- Turpeinen, Osmo, Further Studies on the Unsaturated Fatty Acids Essential in Nutrition, 15,4:351-366, April, 1938.
- Hart, James P., unpublished correspondence, Los Angeles, California to Vitamin Products Company, Milwaukee, Wisconsin.