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Among the many theories regarding the controlling factors for immunity to dental caries, "potential alkalinity" has been stressed by many as playing the controlling role. It is very clear that a satisfactory approach to this problem will require the consideration of many diets which have been competent to establish and maintain a very high immunity. No modern civilization provides such a control group, since dental caries are active and in certain groups rampant among the individuals of all of our modernized peoples. It is for this reason I have been making expeditions during several years to reach the remnants of primitive racial stocks who, like their ancestors, are characterized by a very high immunity to dental caries and who by their isolation make possible a critical study of the variables at the point of contact with modern civilization where the high immunity changes to a high susceptibility to tooth decay.